1qpi

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[[Image:1qpi.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1qpi| PDB=1qpi | SCENE= }}
{{STRUCTURE_1qpi| PDB=1qpi | SCENE= }}
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'''CRYSTAL STRUCTURE OF TETRACYCLINE REPRESSOR/OPERATOR COMPLEX'''
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===CRYSTAL STRUCTURE OF TETRACYCLINE REPRESSOR/OPERATOR COMPLEX===
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==Overview==
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The tetracycline repressor (TetR) regulates the most abundant resistance mechanism against the antibiotic tetracycline in grain-negative bacteria. The TetR protein and its mutants are commonly used as control elements to regulate gene expression in higher eukaryotes. We present the crystal structure of the TetR homodimer in complex with its palindromic DNA operator at 2.5 A resolution. Comparison to the structure of TetR in complex with the inducer tetracycline-Mg2+ allows the mechanism of induction to be deduced. Inducer binding in the repressor core initiates conformational changes starting with C-terminal unwinding and shifting of the short helix a6 in each monomer. This forces a pendulum-like motion of helix a4, which increases the separation of the attached DNA binding domains by 3 A, abolishing the affinity of TetR for its operator DNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 10700280 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10700280}}
==About this Structure==
==About this Structure==
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[[Category: Repressor/operator complex]]
[[Category: Repressor/operator complex]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:49:11 2008''

Revision as of 02:49, 28 July 2008

Image:1qpi.png

Template:STRUCTURE 1qpi

CRYSTAL STRUCTURE OF TETRACYCLINE REPRESSOR/OPERATOR COMPLEX

Template:ABSTRACT PUBMED 10700280

About this Structure

1QPI is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system., Orth P, Schnappinger D, Hillen W, Saenger W, Hinrichs W, Nat Struct Biol. 2000 Mar;7(3):215-9. PMID:10700280

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