1qqv

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[[Image:1qqv.gif|left|200px]]
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{{Seed}}
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[[Image:1qqv.png|left|200px]]
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{{STRUCTURE_1qqv| PDB=1qqv | SCENE= }}
{{STRUCTURE_1qqv| PDB=1qqv | SCENE= }}
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'''SOLUTION STRUCTURE OF THE HEADPIECE DOMAIN OF CHICKEN VILLIN'''
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===SOLUTION STRUCTURE OF THE HEADPIECE DOMAIN OF CHICKEN VILLIN===
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==Overview==
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A growing family of F-actin-bundling proteins harbors a modular F-actin-binding headpiece domain at the C terminus. Headpiece provides one of the two F-actin-binding sites essential for filament bundling. Here, we report the first structure of a functional headpiece domain. The NMR structure of chicken villin headpiece (HP67) reveals two subdomains that share a tightly packed hydrophobic core. The N-terminal subdomain contains bends, turns, and a four-residue alpha-helix as well as a buried histidine residue that imparts a pH-dependent folding. The C-terminal subdomain is composed of three alpha-helices and its folding is pH-independent. Two residues previously implicated in F-actin-binding form a buried salt-bridge between the N and C-terminal subdomains. The rest of the identified actin-binding residues are solvent-exposed and map onto a unique F-actin-binding surface.
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(as it appears on PubMed at http://www.pubmed.gov), where 10600386 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10600386}}
==About this Structure==
==About this Structure==
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1QQV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQV OCA].
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1QQV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQV OCA].
==Reference==
==Reference==
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[[Category: F-actin binding domain]]
[[Category: F-actin binding domain]]
[[Category: Salt-bridge]]
[[Category: Salt-bridge]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:36:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:50:21 2008''

Revision as of 20:50, 27 July 2008

Image:1qqv.png

Template:STRUCTURE 1qqv

SOLUTION STRUCTURE OF THE HEADPIECE DOMAIN OF CHICKEN VILLIN

Template:ABSTRACT PUBMED 10600386

About this Structure

1QQV is a Single protein structure of sequence from Gallus gallus. Full experimental information is available from OCA.

Reference

NMR structure of an F-actin-binding "headpiece" motif from villin., Vardar D, Buckley DA, Frank BS, McKnight CJ, J Mol Biol. 1999 Dec 17;294(5):1299-310. PMID:10600386

Page seeded by OCA on Sun Jul 27 23:50:21 2008

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