1qrn

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[[Image:1qrn.gif|left|200px]]
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{{Seed}}
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[[Image:1qrn.png|left|200px]]
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{{STRUCTURE_1qrn| PDB=1qrn | SCENE= }}
{{STRUCTURE_1qrn| PDB=1qrn | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN A6 TCR COMPLEXED WITH HLA-A2 BOUND TO ALTERED HTLV-1 TAX PEPTIDE P6A'''
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===CRYSTAL STRUCTURE OF HUMAN A6 TCR COMPLEXED WITH HLA-A2 BOUND TO ALTERED HTLV-1 TAX PEPTIDE P6A===
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==Overview==
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The interactions of three singly substituted peptide variants of the HTLV-1 Tax peptide bound to HLA-A2 with the A6 T cell receptor have been studied using T cell assays, kinetic and thermodynamic measurements, and X-ray crystallography. The three peptide/MHC ligands include weak agonists and antagonists with different affinities for TCR. The three-dimensional structures of the three A6-TCR/peptide/HLA-A2 complexes are remarkably similar to each other and to the wild-type agonist complex, with minor adjustments at the interface to accommodate the peptide substitutions (P6A, V7R, and Y8A). The lack of correlation between structural changes and the type of T cell signals induced provides direct evidence that different signals are not generated by different ligand-induced conformational changes in the alphabeta TCR.
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The line below this paragraph, {{ABSTRACT_PUBMED_10435578}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10435578 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10435578}}
==About this Structure==
==About this Structure==
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[[Category: Tax]]
[[Category: Tax]]
[[Category: Tcr]]
[[Category: Tcr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:37:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:29:56 2008''

Revision as of 03:30, 28 July 2008

Image:1qrn.png

Template:STRUCTURE 1qrn

CRYSTAL STRUCTURE OF HUMAN A6 TCR COMPLEXED WITH HLA-A2 BOUND TO ALTERED HTLV-1 TAX PEPTIDE P6A

Template:ABSTRACT PUBMED 10435578

About this Structure

1QRN is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical., Ding YH, Baker BM, Garboczi DN, Biddison WE, Wiley DC, Immunity. 1999 Jul;11(1):45-56. PMID:10435578

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