1qrq

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[[Image:1qrq.gif|left|200px]]
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{{Seed}}
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[[Image:1qrq.png|left|200px]]
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{{STRUCTURE_1qrq| PDB=1qrq | SCENE= }}
{{STRUCTURE_1qrq| PDB=1qrq | SCENE= }}
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'''STRUCTURE OF A VOLTAGE-DEPENDENT K+ CHANNEL BETA SUBUNIT'''
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===STRUCTURE OF A VOLTAGE-DEPENDENT K+ CHANNEL BETA SUBUNIT===
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==Overview==
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The integral membrane subunits of many voltage-dependent potassium channels are associated with an additional protein known as the beta subunit. One function of beta subunits is to modify K+ channel gating. We have determined the structure of the conserved core of mammalian beta subunits by X-ray crystallography at 2.8 A resolution. Like the integral membrane component of K+ channels, beta subunits form a four-fold symmetric structure. Each subunit is an oxidoreductase enzyme complete with a nicotinamide co-factor in its active site. Several structural features of the enzyme active site, including its location with respect to the four-fold axis, imply that it may interact directly or indirectly with the K+ channel's voltage sensor. This structure suggests a mechanism for coupling membrane electrical excitability directly to chemistry of the cell.
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The line below this paragraph, {{ABSTRACT_PUBMED_10399921}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10399921 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10399921}}
==About this Structure==
==About this Structure==
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[[Category: Tim barrel]]
[[Category: Tim barrel]]
[[Category: Voltage-dependent potassium channel]]
[[Category: Voltage-dependent potassium channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:37:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:36:46 2008''

Revision as of 00:36, 28 July 2008

Image:1qrq.png

Template:STRUCTURE 1qrq

STRUCTURE OF A VOLTAGE-DEPENDENT K+ CHANNEL BETA SUBUNIT

Template:ABSTRACT PUBMED 10399921

About this Structure

1QRQ is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of a voltage-dependent K+ channel beta subunit., Gulbis JM, Mann S, MacKinnon R, Cell. 1999 Jun 25;97(7):943-52. PMID:10399921

Page seeded by OCA on Mon Jul 28 03:36:46 2008

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