1qtg

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[[Image:1qtg.gif|left|200px]]
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{{STRUCTURE_1qtg| PDB=1qtg | SCENE= }}
{{STRUCTURE_1qtg| PDB=1qtg | SCENE= }}
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'''AVERAGED NMR MODEL OF SWITCH ARC, A DOUBLE MUTANT OF ARC REPRESSOR'''
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===AVERAGED NMR MODEL OF SWITCH ARC, A DOUBLE MUTANT OF ARC REPRESSOR===
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==Overview==
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A "switch" mutant of the Arc repressor homodimer was constructed by interchanging the sequence positions of a hydrophobic core residue, leucine 12, and an adjacent surface polar residue, asparagine 11, in each strand of an intersubunit beta sheet. The mutant protein adopts a fold in which each beta strand is replaced by a right-handed helix and side chains in this region undergo significant repacking. The observed structural changes allow the protein to maintain solvent exposure of polar side chains and optimal burial of hydrophobic side chains. These results suggest that new protein folds can evolve from existing folds without drastic or large-scale mutagenesis.
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(as it appears on PubMed at http://www.pubmed.gov), where 10195898 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10195898}}
==About this Structure==
==About this Structure==
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1QTG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p22 Enterobacteria phage p22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTG OCA].
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1QTG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p22 Enterobacteria phage p22]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTG OCA].
==Reference==
==Reference==
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[[Category: Right-handed helix]]
[[Category: Right-handed helix]]
[[Category: Structural change]]
[[Category: Structural change]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:41:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:11:14 2008''

Revision as of 08:11, 29 July 2008

Image:1qtg.png

Template:STRUCTURE 1qtg

AVERAGED NMR MODEL OF SWITCH ARC, A DOUBLE MUTANT OF ARC REPRESSOR

Template:ABSTRACT PUBMED 10195898

About this Structure

1QTG is a Single protein structure of sequence from Enterobacteria phage p22. Full experimental information is available from OCA.

Reference

Evolution of a protein fold in vitro., Cordes MH, Walsh NP, McKnight CJ, Sauer RT, Science. 1999 Apr 9;284(5412):325-8. PMID:10195898

Page seeded by OCA on Tue Jul 29 11:11:14 2008

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