7ld0
From Proteopedia
(Difference between revisions)
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<StructureSection load='7ld0' size='340' side='right'caption='[[7ld0]], [[Resolution|resolution]] 3.10Å' scene=''> | <StructureSection load='7ld0' size='340' side='right'caption='[[7ld0]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LD0 FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ld0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ld0 OCA], [https://pdbe.org/7ld0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ld0 RCSB], [https://www.ebi.ac.uk/pdbsum/7ld0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ld0 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ld0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ld0 OCA], [https://pdbe.org/7ld0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ld0 RCSB], [https://www.ebi.ac.uk/pdbsum/7ld0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ld0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/SARM1_HUMAN SARM1_HUMAN] Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.<ref>PMID:15123841</ref> <ref>PMID:16964262</ref> <ref>PMID:16985498</ref> <ref>PMID:20306472</ref> | ||
==See Also== | ==See Also== | ||
*[[SARM1 3D structures|SARM1 3D structures]] | *[[SARM1 3D structures|SARM1 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Gu W]] | [[Category: Gu W]] | ||
Current revision
Cryo-EM structure of ligand-free Human SARM1
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Categories: Large Structures | Gu W | Jia X | Kobe B | Landsberg MJ | Luo Z | Nanson JD | Ve T
