1qu7

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[[Image:1qu7.jpg|left|200px]]
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{{STRUCTURE_1qu7| PDB=1qu7 | SCENE= }}
{{STRUCTURE_1qu7| PDB=1qu7 | SCENE= }}
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'''FOUR HELICAL-BUNDLE STRUCTURE OF THE CYTOPLASMIC DOMAIN OF A SERINE CHEMOTAXIS RECEPTOR'''
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===FOUR HELICAL-BUNDLE STRUCTURE OF THE CYTOPLASMIC DOMAIN OF A SERINE CHEMOTAXIS RECEPTOR===
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==Overview==
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The bacterial chemotaxis receptors are transmembrane receptors with a simple signalling pathway which has elements relevant to the general understanding of signal recognition and transduction across membranes, how signals are relayed between molecules in a pathway, and how adaptation to a persistent signal is achieved. In contrast to many mammalian receptors which signal by oligomerizing upon ligand binding, the chemotaxis receptors are dimeric even in the absence of their ligands, and their signalling does not depend on a monomer-dimer equilibrium. Bacterial chemotaxis receptors are composed of a ligand-binding domain, a transmembrane domain consisting of two helices TM1 and TM2, and a cytoplasmic domain. All known bacterial chemotaxis receptors have a highly conserved cytoplasmic domain, which unites signals from different ligand domains into a single signalling pathway to flagella motors. Here we report the crystal structure of the cytoplasmic domain of a serine chemotaxis receptor of Escherichia coli, which reveals a 200 A-long coiled-coil of two antiparallel helices connected by a 'U-turn'. Two of these domains form a long, supercoiled, four-helical bundle in the cytoplasmic portion of the receptor.
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The line below this paragraph, {{ABSTRACT_PUBMED_10466731}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10466731 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10466731}}
==About this Structure==
==About this Structure==
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[[Category: Four helical-bundle]]
[[Category: Four helical-bundle]]
[[Category: Serine]]
[[Category: Serine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:42:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:19:52 2008''

Revision as of 08:19, 29 July 2008

Image:1qu7.png

Template:STRUCTURE 1qu7

FOUR HELICAL-BUNDLE STRUCTURE OF THE CYTOPLASMIC DOMAIN OF A SERINE CHEMOTAXIS RECEPTOR

Template:ABSTRACT PUBMED 10466731

About this Structure

1QU7 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Four-helical-bundle structure of the cytoplasmic domain of a serine chemotaxis receptor., Kim KK, Yokota H, Kim SH, Nature. 1999 Aug 19;400(6746):787-92. PMID:10466731

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