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1qu3

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[[Image:1qu3.gif|left|200px]]
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{{Seed}}
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[[Image:1qu3.png|left|200px]]
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{{STRUCTURE_1qu3| PDB=1qu3 | SCENE= }}
{{STRUCTURE_1qu3| PDB=1qu3 | SCENE= }}
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'''INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN'''
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===INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN===
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==Overview==
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Isoleucyl-transfer RNA (tRNA) synthetase (IleRS) joins Ile to tRNA(Ile) at its synthetic active site and hydrolyzes incorrectly acylated amino acids at its editing active site. The 2.2 angstrom resolution crystal structure of Staphylococcus aureus IleRS complexed with tRNA(Ile) and Mupirocin shows the acceptor strand of the tRNA(Ile) in the continuously stacked, A-form conformation with the 3' terminal nucleotide in the editing active site. To position the 3' terminus in the synthetic active site, the acceptor strand must adopt the hairpinned conformation seen in tRNA(Gln) complexed with its synthetase. The amino acid editing activity of the IleRS may result from the incorrect products shuttling between the synthetic and editing active sites, which is reminiscent of the editing mechanism of DNA polymerases.
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The line below this paragraph, {{ABSTRACT_PUBMED_10446055}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10446055 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10446055}}
==About this Structure==
==About this Structure==
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[[Category: Metal ion]]
[[Category: Metal ion]]
[[Category: Shuttling mechanism]]
[[Category: Shuttling mechanism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:42:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:45:58 2008''

Revision as of 14:46, 28 July 2008

Image:1qu3.png

Template:STRUCTURE 1qu3

INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN

Template:ABSTRACT PUBMED 10446055

About this Structure

1QU3 is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin., Silvian LF, Wang J, Steitz TA, Science. 1999 Aug 13;285(5430):1074-7. PMID:10446055

Page seeded by OCA on Mon Jul 28 17:45:58 2008

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