1qum

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[[Image:1qum.gif|left|200px]]
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{{Seed}}
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[[Image:1qum.png|left|200px]]
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{{STRUCTURE_1qum| PDB=1qum | SCENE= }}
{{STRUCTURE_1qum| PDB=1qum | SCENE= }}
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'''CRYSTAL STRUCTURE OF ESCHERICHIA COLI ENDONUCLEASE IV IN COMPLEX WITH DAMAGED DNA'''
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===CRYSTAL STRUCTURE OF ESCHERICHIA COLI ENDONUCLEASE IV IN COMPLEX WITH DAMAGED DNA===
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==Overview==
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Endonuclease IV is the archetype for a conserved apurinic/apyrimidinic (AP) endonuclease family that primes DNA repair synthesis by cleaving the DNA backbone 5' of AP sites. The crystal structures of Endonuclease IV and its AP-DNA complex at 1.02 and 1.55 A resolution reveal how an alpha8beta8 TIM barrel fold can bind dsDNA. Enzyme loops intercalate side chains at the abasic site, compress the DNA backbone, bend the DNA approximately 90 degrees, and promote double-nucleotide flipping to sequester the extrahelical AP site in an enzyme pocket that excludes undamaged nucleotides. These structures suggest three Zn2+ ions directly participate in phosphodiester bond cleavage and prompt hypotheses that double-nucleotide flipping and sharp bending by AP endonucleases provide exquisite damage specificity while aiding subsequent base excision repair pathway progression.
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The line below this paragraph, {{ABSTRACT_PUBMED_10458614}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10458614 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10458614}}
==About this Structure==
==About this Structure==
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[[Category: Tim barrel]]
[[Category: Tim barrel]]
[[Category: Trinuclear zn cluster]]
[[Category: Trinuclear zn cluster]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:43:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:58:01 2008''

Revision as of 21:58, 28 July 2008

Image:1qum.png

Template:STRUCTURE 1qum

CRYSTAL STRUCTURE OF ESCHERICHIA COLI ENDONUCLEASE IV IN COMPLEX WITH DAMAGED DNA

Template:ABSTRACT PUBMED 10458614

About this Structure

1QUM is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis., Hosfield DJ, Guan Y, Haas BJ, Cunningham RP, Tainer JA, Cell. 1999 Aug 6;98(3):397-408. PMID:10458614

Page seeded by OCA on Tue Jul 29 00:58:01 2008

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