1qv8

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{{STRUCTURE_1qv8| PDB=1qv8 | SCENE= }}
{{STRUCTURE_1qv8| PDB=1qv8 | SCENE= }}
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'''B-DNA Dodecamer d(CGCGAATTCGCG)2 complexed with proamine'''
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===B-DNA Dodecamer d(CGCGAATTCGCG)2 complexed with proamine===
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==Overview==
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New analogues of the minor groove binding ligand Hoechst 33342 have been investigated in an attempt to improve radioprotective activity. The synthesis, DNA binding, and in vitro radioprotective properties of methylproamine, the most potent derivative, are reported. Experiments with V79 cells have shown that methylproamine is approximately 100-fold more potent than the classical aminothiol radioprotector WR1065. The crystal structures of methylproamine and proamine complexes with the dodecamer d(CGCGAATTCGCG)(2) confirm that the new analogues also are minor groove binders. It is proposed that the DNA-bound methylproamine ligand acts as a reducing agent by an electron transfer mechanism, repairing transient radiation-induced oxidizing species on DNA.
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{{ABSTRACT_PUBMED_14871839}}
==About this Structure==
==About this Structure==
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[[Category: B-dna]]
[[Category: B-dna]]
[[Category: Minor groove binder]]
[[Category: Minor groove binder]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:44:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:48:33 2008''

Revision as of 13:48, 27 July 2008

Image:1qv8.png

Template:STRUCTURE 1qv8

B-DNA Dodecamer d(CGCGAATTCGCG)2 complexed with proamine

Template:ABSTRACT PUBMED 14871839

About this Structure

Full crystallographic information is available from OCA.

Reference

In vitro studies with methylproamine: a potent new radioprotector., Martin RF, Broadhurst S, Reum ME, Squire CJ, Clark GR, Lobachevsky PN, White JM, Clark C, Sy D, Spotheim-Maurizot M, Kelly DP, Cancer Res. 2004 Feb 1;64(3):1067-70. PMID:14871839

Page seeded by OCA on Sun Jul 27 16:48:33 2008

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