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1qvi

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[[Image:1qvi.gif|left|200px]]
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{{STRUCTURE_1qvi| PDB=1qvi | SCENE= }}
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'''Crystal structure of scallop myosin S1 in the pre-power stroke state to 2.6 Angstrom resolution: flexibility and function in the head'''
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===Crystal structure of scallop myosin S1 in the pre-power stroke state to 2.6 Angstrom resolution: flexibility and function in the head===
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==Overview==
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We have extended the X-ray structure determination of the complete scallop myosin head in the pre-power stroke state to 2.6 A resolution, allowing an atomic comparison of the three major (weak actin binding) states of various myosins. We can now account for conformational differences observed in crystal structures in the so-called "pliant region" at the motor domain-lever arm junction between scallop and vertebrate smooth muscle myosins. A hinge, which may contribute to the compliance of the myosin crossbridge, has also been identified for the first time within the regulatory light-chain domain of the lever arm. Analysis of temperature factors of key joints of the motor domain, especially the SH1 helix, provides crystallographic evidence for the existence of the "internally uncoupled" state in diverse isoforms. The agreement between structural and solution studies reinforces the view that the unwinding of the SH1 helix is a part of the cross-bridge cycle in many myosins.
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The line below this paragraph, {{ABSTRACT_PUBMED_14656445}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14656445 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14656445}}
==About this Structure==
==About this Structure==
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[[Category: Pre-power stroke state]]
[[Category: Pre-power stroke state]]
[[Category: Sh1 helix]]
[[Category: Sh1 helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:44:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:53:25 2008''

Revision as of 13:53, 27 July 2008

Image:1qvi.png

Template:STRUCTURE 1qvi

Crystal structure of scallop myosin S1 in the pre-power stroke state to 2.6 Angstrom resolution: flexibility and function in the head

Template:ABSTRACT PUBMED 14656445

About this Structure

1QVI is a Protein complex structure of sequences from Argopecten irradians. Full crystallographic information is available from OCA.

Reference

Crystal structure of scallop Myosin s1 in the pre-power stroke state to 2.6 a resolution: flexibility and function in the head., Gourinath S, Himmel DM, Brown JH, Reshetnikova L, Szent-Gyorgyi AG, Cohen C, Structure. 2003 Dec;11(12):1621-7. PMID:14656445

Page seeded by OCA on Sun Jul 27 16:53:25 2008

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