1qxp

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[[Image:1qxp.jpg|left|200px]]
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{{Seed}}
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[[Image:1qxp.png|left|200px]]
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{{STRUCTURE_1qxp| PDB=1qxp | SCENE= }}
{{STRUCTURE_1qxp| PDB=1qxp | SCENE= }}
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'''Crystal Structure of a mu-like calpain'''
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===Crystal Structure of a mu-like calpain===
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==Overview==
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The two Ca2+-dependent cysteine proteases, micro- and m-calpain, are involved in various Ca2+-linked signal pathways but differ markedly in their Ca2+ requirements for activation. We have determined the structure of a micro-like calpain, which has 85% micro-calpain sequence (the first 48 and the last 62 residues of the large subunit are those from m-calpain) and a low Ca2+ requirement. This construct was used because micro-calpain itself is too poorly expressed. The structure of micro-like calpain is very similar in overall fold to that of m-calpain as expected, but differs significantly in two aspects. In comparison with m-calpain, the catalytic triad residues in micro-like calpain, His and Cys, are much closer together in the absence of Ca2+, and significant portions of the Ca2+ binding EF-hand motifs are disordered and more flexible. These structural differences imply that Ca2+-free micro-calpain may represent a partially activated structure, requiring lower Ca2+ concentration to trigger its activation.
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The line below this paragraph, {{ABSTRACT_PUBMED_14656436}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14656436 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14656436}}
==About this Structure==
==About this Structure==
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[[Category: M-calpain]]
[[Category: M-calpain]]
[[Category: Mu-calpain]]
[[Category: Mu-calpain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:49:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:07:34 2008''

Revision as of 05:07, 28 July 2008

Image:1qxp.png

Template:STRUCTURE 1qxp

Crystal Structure of a mu-like calpain

Template:ABSTRACT PUBMED 14656436

About this Structure

1QXP is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a micro-like calpain reveals a partially activated conformation with low Ca2+ requirement., Pal GP, De Veyra T, Elce JS, Jia Z, Structure. 2003 Dec;11(12):1521-6. PMID:14656436

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