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1qys

From Proteopedia

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[[Image:1qys.gif|left|200px]]
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==Overview==
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{{ABSTRACT_14631033}}
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A major challenge of computational protein design is the creation of novel proteins with arbitrarily chosen three-dimensional structures. Here, we used a general computational strategy that iterates between sequence design and structure prediction to design a 93-residue alpha/beta protein called Top7 with a novel sequence and topology. Top7 was found experimentally to be folded and extremely stable, and the x-ray crystal structure of Top7 is similar (root mean square deviation equals 1.2 angstroms) to the design model. The ability to design a new protein fold makes possible the exploration of the large regions of the protein universe not yet observed in nature.
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==About this Structure==
==About this Structure==
The following page contains interesting information on the relation of 1QYS with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QYS OCA].
The following page contains interesting information on the relation of 1QYS with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QYS OCA].
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==Reference==
 
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Design of a novel globular protein fold with atomic-level accuracy., Kuhlman B, Dantas G, Ireton GC, Varani G, Stoddard BL, Baker D, Science. 2003 Nov 21;302(5649):1364-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14631033 14631033]
 
[[Category: Designer Proteins]]
[[Category: Designer Proteins]]
[[Category: Baker, D.]]
[[Category: Baker, D.]]
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[[Category: Computationally designed]]
[[Category: Computationally designed]]
[[Category: Novel fold]]
[[Category: Novel fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:51:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:53:05 2008''

Revision as of 14:53, 26 June 2008

Image:1qys.png

Template:STRUCTURE 1qys

Crystal structure of Top7: A computationally designed protein with a novel fold


Template:ABSTRACT 14631033

About this Structure

The following page contains interesting information on the relation of 1QYS with [Designer Proteins]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:53:05 2008

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