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1qz0

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{{STRUCTURE_1qz0| PDB=1qz0 | SCENE= }}
{{STRUCTURE_1qz0| PDB=1qz0 | SCENE= }}
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'''Crystal Structure of the Yersinia Pestis Phosphatase YopH in Complex with a Phosphotyrosyl Mimetic-Containing Hexapeptide'''
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===Crystal Structure of the Yersinia Pestis Phosphatase YopH in Complex with a Phosphotyrosyl Mimetic-Containing Hexapeptide===
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==Overview==
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Yersinia pestis, the causative agent of bubonic plague, secretes a eukaryotic-like protein tyrosine phosphatase (PTPase) termed Yersinia outer protein H (YopH) that is essential for virulence. We have determined, for the first time, the crystal structure of the YopH PTPase domain in complex with a nonhydrolyzable substrate analogue, the hexapeptide mimetic Ac-DADE-F(2)Pmp-L-NH(2). As anticipated, the mode of ligand binding in the active site is similar to the way in which the corresponding phosphohexapeptide binds to the structurally homologous human PTP1B. Unexpectedly, however, the crystal structure also revealed a second substrate-binding site in YopH that is not present in PTP1B. The mode of binding and structural conformation of the hexapeptide analogue is quite different in the two sites. Although the biological function of the second substrate-binding site remains to be investigated, the structure of a substrate analogue in the active site of Y. pestis YopH opens the door for the structure-based design and optimization of therapeutic countermeasures to combat this potential agent of bioterrorism.
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(as it appears on PubMed at http://www.pubmed.gov), where 14609321 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14609321}}
==About this Structure==
==About this Structure==
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[[Category: Ptpase]]
[[Category: Ptpase]]
[[Category: Yoph]]
[[Category: Yoph]]
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Revision as of 05:33, 29 July 2008

Image:1qz0.png

Template:STRUCTURE 1qz0

Crystal Structure of the Yersinia Pestis Phosphatase YopH in Complex with a Phosphotyrosyl Mimetic-Containing Hexapeptide

Template:ABSTRACT PUBMED 14609321

About this Structure

1QZ0 is a Single protein structure of sequence from Yersinia pestis. Full crystallographic information is available from OCA.

Reference

High-resolution structure of the Yersinia pestis protein tyrosine phosphatase YopH in complex with a phosphotyrosyl mimetic-containing hexapeptide., Phan J, Lee K, Cherry S, Tropea JE, Burke TR Jr, Waugh DS, Biochemistry. 2003 Nov 18;42(45):13113-21. PMID:14609321

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