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1qz6

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[[Image:1qz6.jpg|left|200px]]
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{{STRUCTURE_1qz6| PDB=1qz6 | SCENE= }}
{{STRUCTURE_1qz6| PDB=1qz6 | SCENE= }}
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'''Structure of rabbit actin in complex with jaspisamide A'''
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===Structure of rabbit actin in complex with jaspisamide A===
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==Overview==
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Marine macrolide toxins of trisoxazole family target actin with high affinity and specificity and have promising pharmacological properties. We present X-ray structures of actin in complex with two members of this family, kabiramide C and jaspisamide A, at a resolution of 1.45 and 1.6 A, respectively. The structures reveal the absolute stereochemistry of these toxins and demonstrate that their trisoxazole ring interacts with actin subdomain 1 while the aliphatic side chain is inserted into the hydrophobic cavity between actin subdomains 1 and 3. The binding site is essentially the same as the one occupied by the actin-capping domain of the gelsolin superfamily of proteins. The structural evidence suggests that actin filament severing and capping by these toxins is also analogous to that of gelsolin. Consequently, these macrolides may be viewed as small molecule biomimetics of an entire class of actin-binding proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 14578936 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14578936}}
==About this Structure==
==About this Structure==
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[[Category: Toxin]]
[[Category: Toxin]]
[[Category: Trisoxazole]]
[[Category: Trisoxazole]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:52:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:02:40 2008''

Revision as of 09:02, 28 July 2008

Image:1qz6.png

Template:STRUCTURE 1qz6

Structure of rabbit actin in complex with jaspisamide A

Template:ABSTRACT PUBMED 14578936

About this Structure

1QZ6 is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Trisoxazole macrolide toxins mimic the binding of actin-capping proteins to actin., Klenchin VA, Allingham JS, King R, Tanaka J, Marriott G, Rayment I, Nat Struct Biol. 2003 Dec;10(12):1058-63. Epub 2003 Oct 26. PMID:14578936

Page seeded by OCA on Mon Jul 28 12:02:40 2008

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