1qzb

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{{STRUCTURE_1qzb| PDB=1qzb | SCENE= }}
{{STRUCTURE_1qzb| PDB=1qzb | SCENE= }}
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'''Coordinates of the A-site tRNA model fitted into the cryo-EM map of 70S ribosome in the pre-translocational state'''
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===Coordinates of the A-site tRNA model fitted into the cryo-EM map of 70S ribosome in the pre-translocational state===
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==Overview==
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Aminoacyl-tRNAs (aa-tRNAs) are delivered to the ribosome as part of the ternary complex of aa-tRNA, elongation factor Tu (EF-Tu) and GTP. Here, we present a cryo-electron microscopy (cryo-EM) study, at a resolution of approximately 9 A, showing that during the incorporation of the aa-tRNA into the 70S ribosome of Escherichia coli, the flexibility of aa-tRNA allows the initial codon recognition and its accommodation into the ribosomal A site. In addition, a conformational change observed in the GTPase-associated center (GAC) of the ribosomal 50S subunit may provide the mechanism by which the ribosome promotes a relative movement of the aa-tRNA with respect to EF-Tu. This relative rearrangement seems to facilitate codon recognition by the incoming aa-tRNA, and to provide the codon-anticodon recognition-dependent signal for the GTPase activity of EF-Tu. From these new findings we propose a mechanism that can explain the sequence of events during the decoding of mRNA on the ribosome.
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The line below this paragraph, {{ABSTRACT_PUBMED_14566331}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14566331 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14566331}}
==About this Structure==
==About this Structure==
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[[Category: Zavialov, A.]]
[[Category: Zavialov, A.]]
[[Category: A-site trna]]
[[Category: A-site trna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:53:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:51:26 2008''

Revision as of 18:51, 27 July 2008

Image:1qzb.png

Template:STRUCTURE 1qzb

Coordinates of the A-site tRNA model fitted into the cryo-EM map of 70S ribosome in the pre-translocational state

Template:ABSTRACT PUBMED 14566331

About this Structure

Full crystallographic information is available from OCA.

Reference

Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy., Valle M, Zavialov A, Li W, Stagg SM, Sengupta J, Nielsen RC, Nissen P, Harvey SC, Ehrenberg M, Frank J, Nat Struct Biol. 2003 Nov;10(11):899-906. Epub 2003 Oct 19. PMID:14566331

Page seeded by OCA on Sun Jul 27 21:51:26 2008

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