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1qzm

From Proteopedia

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[[Image:1qzm.gif|left|200px]]
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{{STRUCTURE_1qzm| PDB=1qzm | SCENE= }}
{{STRUCTURE_1qzm| PDB=1qzm | SCENE= }}
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'''alpha-domain of ATPase'''
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===alpha-domain of ATPase===
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==Overview==
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The crystal structure of the small, mostly helical alpha domain of the AAA+ module of the Escherichia coli ATP-dependent protease Lon has been solved by single isomorphous replacement combined with anomalous scattering and refined at 1.9A resolution to a crystallographic R factor of 17.9%. This domain, comprising residues 491-584, was obtained by chymotrypsin digestion of the recombinant full-length protease. The alpha domain of Lon contains four alpha helices and two parallel strands and resembles similar domains found in a variety of ATPases and helicases, including the oligomeric proteases HslVU and ClpAP. The highly conserved "sensor-2" Arg residue is located at the beginning of the third helix. Detailed comparison with the structures of 11 similar domains established the putative location of the nucleotide-binding site in this first fragment of Lon for which a crystal structure has become available.
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(as it appears on PubMed at http://www.pubmed.gov), where 15037242 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15037242}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Oligomerization domain]]
[[Category: Oligomerization domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:53:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:21:44 2008''

Revision as of 06:21, 28 July 2008

Image:1qzm.png

Template:STRUCTURE 1qzm

alpha-domain of ATPase

Template:ABSTRACT PUBMED 15037242

About this Structure

1QZM is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the AAA+ alpha domain of E. coli Lon protease at 1.9A resolution., Botos I, Melnikov EE, Cherry S, Khalatova AG, Rasulova FS, Tropea JE, Maurizi MR, Rotanova TV, Gustchina A, Wlodawer A, J Struct Biol. 2004 Apr-May;146(1-2):113-22. PMID:15037242

Page seeded by OCA on Mon Jul 28 09:21:44 2008

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