This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1r02

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1r02.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1r02.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1r02| PDB=1r02 | SCENE= }}
{{STRUCTURE_1r02| PDB=1r02 | SCENE= }}
-
'''Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness'''
+
===Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness===
-
==Overview==
+
<!--
-
Orexin-A and orexin-B (hypocretin-1 and hypocretin-2, respectively) are important hypothalamic neuro-peptides, which are encoded by a single mRNA transcript and stimulate food intake as well as regulate wakefulness. Here we determined the solution structure of orexin-A by NMR spectroscopy and by simulated-annealing calculation. The structural features of orexin-A involve two alpha-helices, with the hydrophobic residues disposed to on one side of helix, and hydrophilic residues to the other. A hydrophilic turn induced by two disulfide bonds provides the key difference between orexin-A and -B. With previous mutagenic studies, the derived structure of orexin-A provides us with a structure-functional view for novel drug design.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15479620}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15479620 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15479620}}
==About this Structure==
==About this Structure==
-
1R02 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA].
+
1R02 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA].
==Reference==
==Reference==
Line 27: Line 31:
[[Category: Helix-loop-helix]]
[[Category: Helix-loop-helix]]
[[Category: Turn]]
[[Category: Turn]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:54:39 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:00:58 2008''

Revision as of 04:01, 28 July 2008

Image:1r02.png

Template:STRUCTURE 1r02

Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness

Template:ABSTRACT PUBMED 15479620

About this Structure

1R02 is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution structure of human orexin-A: regulator of appetite and wakefulness., Kim HY, Hong E, Kim JI, Lee W, J Biochem Mol Biol. 2004 Sep 30;37(5):565-73. PMID:15479620

Page seeded by OCA on Mon Jul 28 07:00:58 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1r02"
Personal tools