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1r0o

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[[Image:1r0o.gif|left|200px]]
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{{STRUCTURE_1r0o| PDB=1r0o | SCENE= }}
{{STRUCTURE_1r0o| PDB=1r0o | SCENE= }}
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'''Crystal Structure of the Heterodimeric Ecdysone Receptor DNA-binding Complex'''
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===Crystal Structure of the Heterodimeric Ecdysone Receptor DNA-binding Complex===
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==Overview==
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Ecdysteroids initiate molting and metamorphosis in insects via a heterodimeric receptor consisting of the ecdysone receptor (EcR) and ultraspiracle (USP). The EcR-USP heterodimer preferentially mediates transcription through highly degenerate pseudo-palindromic response elements, resembling inverted repeats of 5'-AGGTCA-3' separated by 1 bp (IR-1). The requirement for a heterodimeric arrangement of EcR-USP subunits to bind to a symmetric DNA is unusual within the nuclear receptor superfamily. We describe the 2.24 A structure of the EcR-USP DNA-binding domain (DBD) heterodimer bound to an idealized IR-1 element. EcR and USP use similar surfaces, and rely on the deformed minor groove of the DNA to establish protein-protein contacts. As retinoid X receptor (RXR) is the mammalian homolog of USP, we also solved the 2.60 A crystal structure of the EcR-RXR DBD heterodimer on IR-1 and found the dimerization and DNA-binding interfaces to be the same as in the EcR-USP complex. Sequence alignments indicate that the EcR-RXR heterodimer is an important model for understanding how the FXR-RXR heterodimer binds to IR-1 sites.
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(as it appears on PubMed at http://www.pubmed.gov), where 14592980 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14592980}}
==About this Structure==
==About this Structure==
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[[Category: Nuclear receptor]]
[[Category: Nuclear receptor]]
[[Category: Ultraspiracle]]
[[Category: Ultraspiracle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:55:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:10:49 2008''

Revision as of 00:10, 29 July 2008

Image:1r0o.png

Template:STRUCTURE 1r0o

Crystal Structure of the Heterodimeric Ecdysone Receptor DNA-binding Complex

Template:ABSTRACT PUBMED 14592980

About this Structure

1R0O is a Protein complex structure of sequences from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structure of the heterodimeric ecdysone receptor DNA-binding complex., Devarakonda S, Harp JM, Kim Y, Ozyhar A, Rastinejad F, EMBO J. 2003 Nov 3;22(21):5827-40. PMID:14592980

Page seeded by OCA on Tue Jul 29 03:10:49 2008

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