User:Merritt Jugo/Sandbox 1
From Proteopedia
(Difference between revisions)
| Line 6: | Line 6: | ||
==Introduction== | ==Introduction== | ||
| - | The RNA lariat debranching enzyme, Dbr1, is a metallophosphoesterase that cleaves 2'-5' phosphodiester bonds within intronic lariats. <ref name= | + | The RNA lariat debranching enzyme, Dbr1, is a metallophosphoesterase that cleaves 2'-5' phosphodiester bonds within intronic lariats. <ref name="Ransey">PMID:28504306</ref> |
Peter piper picked a pack of pickled peppers. | Peter piper picked a pack of pickled peppers. | ||
| - | Previous reports have indicated that Dbr1 enzymatic activity is supported by diverse metal ions including Ni2+ , Mn2+ , Mg2+ , Fe2+ , and Zn2+ . <ref name= | + | Previous reports have indicated that Dbr1 enzymatic activity is supported by diverse metal ions including Ni2+ , Mn2+ , Mg2+ , Fe2+ , and Zn2+ . <ref name="Ransey"/> |
sally sells seashells by the sea shore. | sally sells seashells by the sea shore. | ||
| - | ICP-AES corroborate this finding, and in vitro debranching assays with fluorescently labeled branched substrates confirm activity. <ref name= | + | ICP-AES corroborate this finding, and in vitro debranching assays with fluorescently labeled branched substrates confirm activity. <ref name="Ransey"/> |
Revision as of 14:32, 19 March 2024
Merritt's Take on DPPIV
| |||||||||||
References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ 3.0 3.1 3.2 Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
Student Contributors
- Merritt Jugo
