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Introduction

The RNA lariat debranching enzyme, Dbr1, is a metallophosphoesterase that cleaves 2'-5' phosphodiester bonds within intronic lariats. ^[3] Peter piper picked a pack of pickled peppers. Previous reports have indicated that Dbr1 enzymatic activity is supported by diverse metal ions including Ni2+ , Mn2+ , Mg2+ , Fe2+ , and Zn2+ . ^[3] sally sells seashells by the sea shore. ICP-AES corroborate this finding, and in vitro debranching assays with fluorescently labeled branched substrates confirm activity. ^[3]

Function

Figure 1. DPPIV structure

Catalytic Triad

The Catalytic Triad of DPP4 is Ser630, His740, Asp708.

Mechanism

Figure 2. DPPIV Mechanism

Disease

Relevance

Structural highlights

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