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1r5c

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{{STRUCTURE_1r5c| PDB=1r5c | SCENE= }}
{{STRUCTURE_1r5c| PDB=1r5c | SCENE= }}
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'''X-ray structure of the complex of Bovine seminal ribonuclease swapping dimer with d(CpA)'''
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===X-ray structure of the complex of Bovine seminal ribonuclease swapping dimer with d(CpA)===
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==Overview==
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Bovine seminal ribonuclease (BS-RNase) is a unique member of the pancreatic-like ribonuclease superfamily. This enzyme exists as two conformational isomers with distinctive biological properties. The structure of the major isomer is characterized by the swapping of the N-terminal segment (MxM BS-RNase). In this article, the crystal structures of the ligand-free MxM BS-RNase and its complex with 2'-deoxycitidylyl(3',5')-2'-deoxyadenosine derived from isomorphous crystals have been refined. Interestingly, the comparison between this novel ligand-free form and the previously published sulfate-bound structure reveals significant differences. In particular, the ligand-free MxM BS-RNase is closer to the structure of MxM BS-RNase productive complexes than to the sulfate-bound form. These results reveal that MxM BS-RNase presents a remarkable flexibility, despite the structural constraints of the interchain disulfide bridges and the swapping of the N-terminal helices. These findings have important implications to the ligand binding mechanism of MxM BS-RNase. Indeed, a population shift rather than a substrate-induced conformational transition may occur in the MxM BS-RNase ligand binding process.
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(as it appears on PubMed at http://www.pubmed.gov), where 15048772 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15048772}}
==About this Structure==
==About this Structure==
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[[Category: Ribonuclease]]
[[Category: Ribonuclease]]
[[Category: X-ray diffraction]]
[[Category: X-ray diffraction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:05:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:07:09 2008''

Revision as of 18:07, 28 July 2008

Image:1r5c.png

Template:STRUCTURE 1r5c

X-ray structure of the complex of Bovine seminal ribonuclease swapping dimer with d(CpA)

Template:ABSTRACT PUBMED 15048772

About this Structure

1R5C is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Population shift vs induced fit: the case of bovine seminal ribonuclease swapping dimer., Merlino A, Vitagliano L, Sica F, Zagari A, Mazzarella L, Biopolymers. 2004 Apr 15;73(6):689-95. PMID:15048772

Page seeded by OCA on Mon Jul 28 21:07:09 2008

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