1r5h

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{{STRUCTURE_1r5h| PDB=1r5h | SCENE= }}
{{STRUCTURE_1r5h| PDB=1r5h | SCENE= }}
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'''Crystal Structure of MetAP2 complexed with A320282'''
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===Crystal Structure of MetAP2 complexed with A320282===
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==Overview==
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Substituted 3-amino-2-hydroxyamides and related hydroxyamides and acylhydrazines were identified as inhibitors of human methionine aminopeptidase-2 (MetAP2). Examination of substituents through parallel synthesis and iterative structure-based design allowed the identification of potent inhibitors with good selectivity against MetAP1. Diacylhydrazine 3t (A-357300) was identified as an analogue displaying inhibition of methionine processing and cellular proliferation in human microvascular endothelial cells (HMVEC).
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{{ABSTRACT_PUBMED_15012983}}
==About this Structure==
==About this Structure==
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[[Category: Yang, F.]]
[[Category: Yang, F.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:06:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:46:14 2008''

Revision as of 21:46, 28 July 2008

Image:1r5h.png

Template:STRUCTURE 1r5h

Crystal Structure of MetAP2 complexed with A320282

Template:ABSTRACT PUBMED 15012983

About this Structure

1R5H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2., Sheppard GS, Wang J, Kawai M, BaMaung NY, Craig RA, Erickson SA, Lynch L, Patel J, Yang F, Searle XB, Lou P, Park C, Kim KH, Henkin J, Lesniewski R, Bioorg Med Chem Lett. 2004 Feb 23;14(4):865-8. PMID:15012983

Page seeded by OCA on Tue Jul 29 00:46:14 2008

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