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1r5i

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{{STRUCTURE_1r5i| PDB=1r5i | SCENE= }}
{{STRUCTURE_1r5i| PDB=1r5i | SCENE= }}
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'''Crystal structure of the MAM-MHC complex'''
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===Crystal structure of the MAM-MHC complex===
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==Overview==
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Mycoplasma arthritidis-derived mitogen (MAM) is a superantigen that can activate large fractions of T cells bearing particular TCR Vbeta elements. Here we report the crystal structure of MAM complexed with a major histocompatibility complex (MHC) antigen, HLA-DR1, loaded with haemagglutinin peptide 306-318 (HA). The structure reveals that MAM has a novel fold composed of two alpha-helical domains. This fold is entirely different from that of the pyrogenic superantigens, consisting of a beta-grasped motif and a beta barrel. In the complex, the N-terminal domain of MAM binds orthogonally to the MHC alpha1 domain and the bound HA peptide, and to a lesser extent to the MHC beta1 domain. Two MAM molecules form an asymmetric dimer and cross-link two MHC antigens to form a plausible, dimerized MAM-MHC complex. These data provide the first crystallographic evidence that superantigens can dimerize MHC molecules. Based on our structure, a model of the TCR2MAM2MHC2 complex is proposed.
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(as it appears on PubMed at http://www.pubmed.gov), where 14962388 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14962388}}
==About this Structure==
==About this Structure==
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[[Category: Mhc]]
[[Category: Mhc]]
[[Category: Superantigen]]
[[Category: Superantigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:06:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:05:39 2008''

Revision as of 14:05, 28 July 2008

Image:1r5i.png

Template:STRUCTURE 1r5i

Crystal structure of the MAM-MHC complex

Template:ABSTRACT PUBMED 14962388

About this Structure

1R5I is a Protein complex structure of sequences from Homo sapiens and Mycoplasma arthritidis. Full crystallographic information is available from OCA.

Reference

Crystal structure of Mycoplasma arthritidis mitogen complexed with HLA-DR1 reveals a novel superantigen fold and a dimerized superantigen-MHC complex., Zhao Y, Li Z, Drozd SJ, Guo Y, Mourad W, Li H, Structure. 2004 Feb;12(2):277-88. PMID:14962388

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