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1r5u

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[[Image:1r5u.gif|left|200px]]
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{{Seed}}
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[[Image:1r5u.png|left|200px]]
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{{STRUCTURE_1r5u| PDB=1r5u | SCENE= }}
{{STRUCTURE_1r5u| PDB=1r5u | SCENE= }}
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'''RNA POLYMERASE II TFIIB COMPLEX'''
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===RNA POLYMERASE II TFIIB COMPLEX===
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==Overview==
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The structure of the general transcription factor IIB (TFIIB) in a complex with RNA polymerase II reveals three features crucial for transcription initiation: an N-terminal zinc ribbon domain of TFIIB that contacts the "dock" domain of the polymerase, near the path of RNA exit from a transcribing enzyme; a "finger" domain of TFIIB that is inserted into the polymerase active center; and a C-terminal domain, whose interaction with both the polymerase and with a TATA box-binding protein (TBP)-promoter DNA complex orients the DNA for unwinding and transcription. TFIIB stabilizes an early initiation complex, containing an incomplete RNA-DNA hybrid region. It may interact with the template strand, which sets the location of the transcription start site, and may interfere with RNA exit, which leads to abortive initiation or promoter escape. The trajectory of promoter DNA determined by the C-terminal domain of TFIIB traverses sites of interaction with TFIIE, TFIIF, and TFIIH, serving to define their roles in the transcription initiation process.
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The line below this paragraph, {{ABSTRACT_PUBMED_14963322}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14963322 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14963322}}
==About this Structure==
==About this Structure==
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[[Category: Westover, K D.]]
[[Category: Westover, K D.]]
[[Category: Zinc ribbon]]
[[Category: Zinc ribbon]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:07:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:48:38 2008''

Revision as of 01:48, 28 July 2008

Image:1r5u.png

Template:STRUCTURE 1r5u

RNA POLYMERASE II TFIIB COMPLEX

Template:ABSTRACT PUBMED 14963322

About this Structure

1R5U is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms., Bushnell DA, Westover KD, Davis RE, Kornberg RD, Science. 2004 Feb 13;303(5660):983-8. PMID:14963322

Page seeded by OCA on Mon Jul 28 04:48:38 2008

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