We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1r68

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1r68.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1r68.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1r68| PDB=1r68 | SCENE= }}
{{STRUCTURE_1r68| PDB=1r68 | SCENE= }}
-
'''Role of the amino sugar in DNA binding of disaccharide anthracyclines: crystal structure of MAR70/d(CGATCG) complex'''
+
===Role of the amino sugar in DNA binding of disaccharide anthracyclines: crystal structure of MAR70/d(CGATCG) complex===
-
==Overview==
+
<!--
-
Disaccharide anthracyclines analogues have been shown to exhibit different antitumour activity as compared with parents compounds doxorubicin and daunomycin. Here we report the crystal structure of the disaccharide analog MAR70 complexed with the DNA hexamer d(CGATCG). The structure has been solved at 1.54A resolution and is similar to previous crystallized anthracycline-DNA complexes with both sugar rings of the disaccharide chain lying in the DNA minor groove. Comparison with the structure of MEN10755 another disaccharide anthracycline co-crystallized with the same DNA hexamer suggests a correlation between the position of the amino sugar on the disaccharide chain and the conformation of this moiety when binding to DNA. This is discussed with respect to the influence on drug activity and on the possible interaction with other cellular targets.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15698785}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15698785 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15698785}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Drug-dna complex]]
[[Category: Drug-dna complex]]
[[Category: Right handed dna]]
[[Category: Right handed dna]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:08:01 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:28:51 2008''

Revision as of 14:29, 28 July 2008

Image:1r68.png

Template:STRUCTURE 1r68

Role of the amino sugar in DNA binding of disaccharide anthracyclines: crystal structure of MAR70/d(CGATCG) complex

Template:ABSTRACT PUBMED 15698785

About this Structure

Full crystallographic information is available from OCA.

Reference

Role of the amino sugar in the DNA binding of disaccharide anthracyclines: crystal structure of the complex MAR70/d(CGATCG)., Temperini C, Cirilli M, Aschi M, Ughetto G, Bioorg Med Chem. 2005 Mar 1;13(5):1673-9. PMID:15698785

Page seeded by OCA on Mon Jul 28 17:28:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1r68"
Personal tools