1r6f

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{{Seed}}
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{{STRUCTURE_1r6f| PDB=1r6f | SCENE= }}
{{STRUCTURE_1r6f| PDB=1r6f | SCENE= }}
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'''The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague'''
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===The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague===
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==Overview==
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The LcrV protein (V-antigen) is a multifunctional virulence factor in Yersinia pestis, the causative agent of plague. LcrV regulates the translocation of cytotoxic effector proteins from the bacterium into the cytosol of mammalian cells via a type III secretion system, possesses antihost activities of its own, and is also an active and passive mediator of resistance to disease. Although a crystal structure of this protein has been actively sought for better understanding of its role in pathogenesis, the wild-type LcrV was found to be recalcitrant to crystallization. We employed a surface entropy reduction mutagenesis strategy to obtain crystals of LcrV that diffract to 2.2 A and determined its structure. The refined model reveals a dumbbell-like molecule with a novel fold that includes an unexpected coiled-coil motif, and provides a detailed three-dimensional roadmap for exploring structure-function relationships in this essential virulence determinant.
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(as it appears on PubMed at http://www.pubmed.gov), where 14962390 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14962390}}
==About this Structure==
==About this Structure==
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[[Category: Waugh, D S.]]
[[Category: Waugh, D S.]]
[[Category: Coiled-coil]]
[[Category: Coiled-coil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:08:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:32:34 2008''

Revision as of 11:32, 27 July 2008

Image:1r6f.png

Template:STRUCTURE 1r6f

The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague

Template:ABSTRACT PUBMED 14962390

About this Structure

1R6F is a Single protein structure of sequence from Yersinia pestis. Full crystallographic information is available from OCA.

Reference

The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague., Derewenda U, Mateja A, Devedjiev Y, Routzahn KM, Evdokimov AG, Derewenda ZS, Waugh DS, Structure. 2004 Feb;12(2):301-6. PMID:14962390

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