1tmc
From Proteopedia
(New page: 200px<br /> <applet load="1tmc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tmc, resolution 2.3Å" /> '''THE HTREE-DIMENSIONA...) |
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caption="1tmc, resolution 2.3Å" /> | caption="1tmc, resolution 2.3Å" /> | ||
'''THE HTREE-DIMENSIONAL STRUCTURE OF A CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE MISSING THE ALPHA3 DOMAIN OF THE HEAVY CHAIN'''<br /> | '''THE HTREE-DIMENSIONAL STRUCTURE OF A CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE MISSING THE ALPHA3 DOMAIN OF THE HEAVY CHAIN'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1TMC is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1TMC is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMC OCA]. |
==Reference== | ==Reference== | ||
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[[Category: histocompatibility antigen]] | [[Category: histocompatibility antigen]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:57:45 2008'' |
Revision as of 14:57, 15 February 2008
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THE HTREE-DIMENSIONAL STRUCTURE OF A CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE MISSING THE ALPHA3 DOMAIN OF THE HEAVY CHAIN
Contents |
Overview
Class I major histocompatibility complex (MHC) molecules are ternary, complexes of the soluble serum protein beta 2-microglobulin, MHC heavy, chain, and bound peptide. The first two domains (alpha 1, alpha 2) of the, heavy chain create the peptide binding cleft and the surface that contacts, the T-cell receptor. The third domain (alpha 3) associates with the T-cell, co-receptor, CD8, during T-cell recognition. Here we describe the x-ray, crystal structure of a human class I MHC molecule, HLA-Aw68, from which, the alpha 3 domain has been proteolytically removed. The resulting, molecule shows no gross morphological changes compared to the intact, protein. A decameric peptide complexed with the intact HLA-Aw68 is seen to, bind to the proteolized molecule in the conventional manner, demonstrating, that the alpha 3 domain is not required for the structural integrity of, the molecule or for peptide binding.
Disease
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142800], Ankylosing spondylitis, susceptibility to, 1 OMIM:[142800], Hypoproteinemia, hypercatabolic OMIM:[109700], Stevens-Johnson syndrome, susceptibility to OMIM:[142800]
About this Structure
1TMC is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The three-dimensional structure of a class I major histocompatibility complex molecule missing the alpha 3 domain of the heavy chain., Collins EJ, Garboczi DN, Karpusas MN, Wiley DC, Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1218-21. PMID:7862664
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