1r9g

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{{STRUCTURE_1r9g| PDB=1r9g | SCENE= }}
{{STRUCTURE_1r9g| PDB=1r9g | SCENE= }}
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'''Three-dimensional Structure of YaaE from Bacillus subtilis'''
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===Three-dimensional Structure of YaaE from Bacillus subtilis===
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==Overview==
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The structure of YaaE from Bacillus subtilis was determined at 2.5-A resolution. YaaE is a member of the triad glutamine aminotransferase family and functions in a recently identified alternate pathway for the biosynthesis of vitamin B(6). Proposed active residues include conserved Cys-79, His-170, and Glu-172. YaaE shows similarity to HisH, a glutaminase involved in histidine biosynthesis. YaaD associates with YaaE. A homology model of this protein was constructed. YaaD is predicted to be a (beta/alpha)(8) barrel on the basis of sequence comparisons. The predicted active site includes highly conserved residues 211-216 and 233-235. Finally, a homology model of a putative YaaD-YaaE complex was prepared using the structure of HisH-F as a model. This model predicts that the ammonia molecule generated by YaaE is channeled through the center of the YaaD barrel to the putative YaaD active site.
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The line below this paragraph, {{ABSTRACT_PUBMED_14585832}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14585832 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14585832}}
==About this Structure==
==About this Structure==
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[[Category: Glutaminase]]
[[Category: Glutaminase]]
[[Category: Triad amidotransferase]]
[[Category: Triad amidotransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:14:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:28:28 2008''

Revision as of 05:28, 29 July 2008

Image:1r9g.png

Template:STRUCTURE 1r9g

Three-dimensional Structure of YaaE from Bacillus subtilis

Template:ABSTRACT PUBMED 14585832

About this Structure

1R9G is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of YaaE from Bacillus subtilis, a glutaminase implicated in pyridoxal-5'-phosphate biosynthesis., Bauer JA, Bennett EM, Begley TP, Ealick SE, J Biol Chem. 2004 Jan 23;279(4):2704-11. Epub 2003 Oct 28. PMID:14585832

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