This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1r9i

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1r9i.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1r9i.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1r9i| PDB=1r9i | SCENE= }}
{{STRUCTURE_1r9i| PDB=1r9i | SCENE= }}
-
'''NMR Solution Structure of PIIIA toxin, NMR, 20 structures'''
+
===NMR Solution Structure of PIIIA toxin, NMR, 20 structures===
-
==Overview==
+
<!--
-
Mu-conotoxins are peptide inhibitors of voltage-sensitive sodium channels (VSSCs). Synthetic forms of mu-conotoxins PIIIA and PIIIA-(2-22) were found to inhibit tetrodotoxin (TTX)-sensitive VSSC current but had little effect on TTX-resistant VSSC current in sensory ganglion neurons. In rat brain neurons, these peptides preferentially inhibited the persistent over the transient VSSC current. Radioligand binding assays revealed that PIIIA, PIIIA-(2-22), and mu-conotoxins GIIIB discriminated among TTX-sensitive VSSCs in rat brain, that these and GIIIC discriminated among the corresponding VSSCs in human brain, and GIIIA had low affinity for neuronal VSSCs. (1)H NMR studies found that PIIIA adopts two conformations in solution due to cis/trans isomerization at hydroxyproline 8. The major trans conformation results in a three-dimensional structure that is significantly different from the previously identified conformation of mu-conotoxins GIIIA and GIIIB that selectively target TTX-sensitive muscle VSSCs. Comparison of the structures and activity of PIIIA to muscle-selective mu-conotoxins provides an insight into the structural requirements for inhibition of different TTX-sensitive sodium channels by mu-conotoxins.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12006587}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12006587 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12006587}}
==About this Structure==
==About this Structure==
-
1R9I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_purpurascens Conus purpurascens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9I OCA].
+
1R9I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_purpurascens Conus purpurascens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9I OCA].
==Reference==
==Reference==
Line 35: Line 39:
[[Category: Conotoxin]]
[[Category: Conotoxin]]
[[Category: Cysteine knot]]
[[Category: Cysteine knot]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:14:21 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:29:07 2008''

Revision as of 17:29, 28 July 2008

Image:1r9i.png

Template:STRUCTURE 1r9i

NMR Solution Structure of PIIIA toxin, NMR, 20 structures

Template:ABSTRACT PUBMED 12006587

About this Structure

1R9I is a Single protein structure of sequence from Conus purpurascens. Full experimental information is available from OCA.

Reference

Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels., Nielsen KJ, Watson M, Adams DJ, Hammarstrom AK, Gage PW, Hill JM, Craik DJ, Thomas L, Adams D, Alewood PF, Lewis RJ, J Biol Chem. 2002 Jul 26;277(30):27247-55. Epub 2002 May 2. PMID:12006587

Page seeded by OCA on Mon Jul 28 20:29:07 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1r9i"
Personal tools