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User:Karisma Moll/Sandbox 1
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(Difference between revisions)
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[https://www.sciencedirect.com/science/article/pii/S0304416520301483#t0005 Proline Peptidase Overview] | [https://www.sciencedirect.com/science/article/pii/S0304416520301483#t0005 Proline Peptidase Overview] | ||
=== History === | === History === | ||
| - | + | Dipeptidyl Peptidase IV's role in the inactivation of incretin hormones (MAKE LINK) was discovered in the 1990s. Animal studies were conducted in the late 1990s, followed by human studies in the early 2000s. The first DPPIV inhibitors (sitagliptin, vildagliptin, alogliptin, saxagliptin, and linagliptin) were approved starting in 2006, and now serve as monotherapy or add-on to other therapies in a glucose-lowering capacity. (insert reference) | |
=== Function === | === Function === | ||
town tartness | town tartness | ||
== Structure == | == Structure == | ||
| - | + | ||
<ref name="Hiramatsu">PMID:12646248</ref> | <ref name="Hiramatsu">PMID:12646248</ref> | ||
=== Overview === | === Overview === | ||
Revision as of 14:26, 26 March 2024
DPPIV in Humans
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References
- ↑ 1.0 1.1 Hiramatsu H, Kyono K, Higashiyama Y, Fukushima C, Shima H, Sugiyama S, Inaka K, Yamamoto A, Shimizu R. The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold. Biochem Biophys Res Commun. 2003 Mar 21;302(4):849-54. PMID:12646248
Student Contributors
- Karisma Moll
- Merritt Jugo
- Sam Magnabosco
