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Introduction

Figure 1. The coolest image of this protein EVAH!!!

The human amylin receptor is a G-coupled protein receptor.

Amylin

Amylin is a neuroendocrine hormone that is synthesized with insulin in the beta cells of pancreatic islets. It can cross the blood-brain barrier and regulates glucose homeostasis via inhibiting gastric emptying, inhibiting the release of glucagon, and inducing meal-ending satiety. In doing so, it prevents spikes in blood glucose and overeating, making it a suitable target for Type II Diabetes treatments and therapies. Seeing as Type II Diabetes is a major risk factor for Alzheimer’s Disease, as Type II Diabetes cases continue to increase, there will likely be a spike in Alzheimer’s Disease as well. Therefore, it is vital that amylin, its receptor, and analogs such as pramlintide are understood to aid in rational drug design.

Amidated C-Terminus

G-Coupled Protein Receptor Interactions

RAMPs

Amylin Receptor Functional Overview

Key Interactions

The aids in amylin affinity and the formation of the AMYR3. The of the amylin is a very interesting mutation.

Disease

Pramlintide Analogue

Type II Diabetes

Alzheimer's Disease

The proline mutations can help prevent disease. ^[3]

Relevance

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.