8r4v
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8r4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8r4v OCA], [https://pdbe.org/8r4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8r4v RCSB], [https://www.ebi.ac.uk/pdbsum/8r4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8r4v ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8r4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8r4v OCA], [https://pdbe.org/8r4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8r4v RCSB], [https://www.ebi.ac.uk/pdbsum/8r4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8r4v ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [https://www.uniprot.org/uniprot/SIK3_HUMAN SIK3_HUMAN] The disease is caused by variants affecting the gene represented in this entry. | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/SIK3_HUMAN SIK3_HUMAN] Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity).[UniProtKB:Q6P4S6]<ref>PMID:30232230</ref> <ref>PMID:29211348</ref> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Structure of Salt-inducible kinase 3 in complex with inhibitor
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