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1rbn

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{{STRUCTURE_1rbn| PDB=1rbn | SCENE= }}
{{STRUCTURE_1rbn| PDB=1rbn | SCENE= }}
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'''THE STRUCTURE OF RIBONUCLEASE A DERIVATIVE II AT 2.1 ANGSTROMS RESOLUTION'''
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===THE STRUCTURE OF RIBONUCLEASE A DERIVATIVE II AT 2.1 ANGSTROMS RESOLUTION===
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==Overview==
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The crystal structure of bovine pancreatic ribonuclease A derivative II, a covalent derivative obtained by reaction of 6-chloropurine 9-beta-D-ribofuranosyl 5'-monophosphate with the alpha-amino group of Lys-1, has been determined and refined at 2.1-A resolution with an agreement factor R = 0.166 for 6254 reflections in the resolution shell 8.0 to 2.1 A. Crystals are orthorhombic and belong to space group C222(1) with unit cell parameters a = 75.73 A, b = 57.85 A, and c = 53.26 A. This crystal packing had never been reported before for pancreatic ribonuclease nor its complexes. The structure found is in accordance with the location of p2, B3, and R3 subsites at the N-terminal region of the protein and provides an explanation of the catalytic behavior observed for this derivative. In particular, differences in kinetic parameters and in the pKa value of His-119 between derivative II and native ribonuclease A can be interpreted on the basis of the position of the phosphate moiety within the derivative structure. Some uncertainty remains on the nucleotide sugar conformation determined.
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(as it appears on PubMed at http://www.pubmed.gov), where 8051049 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8051049}}
==About this Structure==
==About this Structure==
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[[Category: Boque, L.]]
[[Category: Boque, L.]]
[[Category: Fita, I.]]
[[Category: Fita, I.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:18:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:11:39 2008''

Revision as of 03:11, 29 July 2008

Image:1rbn.png

Template:STRUCTURE 1rbn

THE STRUCTURE OF RIBONUCLEASE A DERIVATIVE II AT 2.1 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 8051049

About this Structure

1RBN is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structure of ribonuclease A derivative II at 2.1-A resolution., Boque L, Gracia Coll M, Vilanova M, Cuchillo CM, Fita I, J Biol Chem. 1994 Aug 5;269(31):19707-12. PMID:8051049

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