This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1rc2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1rc2.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1rc2.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1rc2| PDB=1rc2 | SCENE= }}
{{STRUCTURE_1rc2| PDB=1rc2 | SCENE= }}
-
'''2.5 Angstrom Resolution X-ray Structure of Aquaporin Z'''
+
===2.5 Angstrom Resolution X-ray Structure of Aquaporin Z===
-
==Overview==
+
<!--
-
Aquaporins are a family of water and small molecule channels found in organisms ranging from bacteria to animals. One of these channels, the E. coli protein aquaporin Z (AqpZ), has been shown to selectively conduct only water at high rates. We have expressed, purified, crystallized, and solved the X-ray structure of AqpZ. The 2.5 A resolution structure of AqpZ suggests aquaporin selectivity results both from a steric mechanism due to pore size and from specific amino acid substitutions that regulate the preference for a hydrophobic or hydrophilic substrate. This structure provides direct evidence on the molecular mechanisms of specificity between water and glycerol in this family of channels from a single species. It is to our knowledge the first atomic resolution structure of a recombinant aquaporin and so provides a platform for combined genetic, mutational, functional, and structural determinations of the mechanisms of aquaporins and, more generally, the assembly of multimeric membrane proteins.
+
The line below this paragraph, {{ABSTRACT_PUBMED_14691544}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 14691544 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_14691544}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Aquaporin]]
[[Category: Aquaporin]]
[[Category: Membrane protein]]
[[Category: Membrane protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:19:13 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:41:46 2008''

Revision as of 01:41, 28 July 2008

Image:1rc2.png

Template:STRUCTURE 1rc2

2.5 Angstrom Resolution X-ray Structure of Aquaporin Z

Template:ABSTRACT PUBMED 14691544

About this Structure

1RC2 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z., Savage DF, Egea PF, Robles-Colmenares Y, O'Connell JD 3rd, Stroud RM, PLoS Biol. 2003 Dec;1(3):E72. Epub 2003 Dec 22. PMID:14691544

Page seeded by OCA on Mon Jul 28 04:41:46 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rc2"
Personal tools