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1rcb

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[[Image:1rcb.gif|left|200px]]
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{{Seed}}
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[[Image:1rcb.png|left|200px]]
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{{STRUCTURE_1rcb| PDB=1rcb | SCENE= }}
{{STRUCTURE_1rcb| PDB=1rcb | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN RECOMBINANT INTERLEUKIN-4 AT 2.25 ANGSTROMS RESOLUTION'''
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===CRYSTAL STRUCTURE OF HUMAN RECOMBINANT INTERLEUKIN-4 AT 2.25 ANGSTROMS RESOLUTION===
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==Overview==
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The crystal structure of human recombinant interleukin-4 (IL-4) has been solved by multiple isomorphous replacement, and refined to an R factor of 0.218 at 2.25 A resolution. The molecule is a left-handed four-helix bundle with a short stretch of beta sheet. The structure bears close resemblance to other cytokines such as granulocyte-macrophage colony stimulating factor (GM-CSF). Although no sequence similarity of IL-4 to GM-CSF and other related cytokines has been previously postulated, structure-based alignment of IL-4 and GM-CSF revealed that the core of the molecules, including large parts of all four helices and extending over half of the molecule, has 30% sequence identity. This may have identified regions which are not only important to maintain structure, but could also play a role in receptor binding.
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The line below this paragraph, {{ABSTRACT_PUBMED_1511746}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1511746 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1511746}}
==About this Structure==
==About this Structure==
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[[Category: Wlodaver, A.]]
[[Category: Wlodaver, A.]]
[[Category: Cytokine]]
[[Category: Cytokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:19:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:14:53 2008''

Revision as of 19:15, 28 July 2008

Image:1rcb.png

Template:STRUCTURE 1rcb

CRYSTAL STRUCTURE OF HUMAN RECOMBINANT INTERLEUKIN-4 AT 2.25 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 1511746

About this Structure

1RCB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human recombinant interleukin-4 at 2.25 A resolution., Wlodawer A, Pavlovsky A, Gustchina A, FEBS Lett. 1992 Aug 31;309(1):59-64. PMID:1511746

Page seeded by OCA on Mon Jul 28 22:14:53 2008

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