1rcw

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{{STRUCTURE_1rcw| PDB=1rcw | SCENE= }}
{{STRUCTURE_1rcw| PDB=1rcw | SCENE= }}
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'''Crystal structure of CT610 from Chlamydia trachomatis'''
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===Crystal structure of CT610 from Chlamydia trachomatis===
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==Overview==
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The Chlamydia protein CADD (Chlamydia protein associating with death domains) has been implicated in the modulation of host cell apoptosis via binding to the death domains of tumor necrosis factor family receptors. Transfection of CADD into mammalian cells induces apoptosis. Here we present the CADD crystal structure, which reveals a dimer of seven-helix bundles. Each bundle contains a di-iron center adjacent to an internal cavity, forming an active site similar to that of methane mono-oxygenase hydrolase. We further show that CADD mutants lacking critical metal-coordinating residues are substantially less effective in inducing apoptosis but retain their ability to bind to death domains. We conclude that CADD is a novel redox protein toxin unique to Chlamydia species and propose that both its redox activity and death domain binding ability are required for its biological activity.
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(as it appears on PubMed at http://www.pubmed.gov), where 15087448 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15087448}}
==About this Structure==
==About this Structure==
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[[Category: Metallo enzyme]]
[[Category: Metallo enzyme]]
[[Category: Redox enzyme]]
[[Category: Redox enzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:20:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:56:52 2008''

Revision as of 01:56, 28 July 2008

Image:1rcw.png

Template:STRUCTURE 1rcw

Crystal structure of CT610 from Chlamydia trachomatis

Template:ABSTRACT PUBMED 15087448

About this Structure

1RCW is a Single protein structure of sequence from Chlamydia trachomatis. Full crystallographic information is available from OCA.

Reference

Structure of the Chlamydia protein CADD reveals a redox enzyme that modulates host cell apoptosis., Schwarzenbacher R, Stenner-Liewen F, Liewen H, Robinson H, Yuan H, Bossy-Wetzel E, Reed JC, Liddington RC, J Biol Chem. 2004 Jul 9;279(28):29320-4. Epub 2004 Apr 15. PMID:15087448

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