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='''Glucagon-Like Peptide 1 Receptor (GLP1-R)'''= | ='''Glucagon-Like Peptide 1 Receptor (GLP1-R)'''= | ||
== Introduction == | == Introduction == | ||
| - | <StructureSection load=' | + | <StructureSection load='6X18' size='340' side='right' caption='GLP bound to the receptor' scene='10/1038821/Receptor/1'> |
Glucagon-Like Peptide 1 Receptor or GLP1-R uses the glucagon-like peptide to signal the body to secrete insulin and inhibit glucagon secretion. When glucose levels in the blood rise (usually after consuming food), GLP-1R activates, creating a signaling cascade to signal cAMP. After the signaling cascade, the final result is the secretion of insulin to the rest of the body. Discovered in 1990s while trying to understand the mechanism of GLP-1 action. The structure was determined using cryogenic electron microscopy. | Glucagon-Like Peptide 1 Receptor or GLP1-R uses the glucagon-like peptide to signal the body to secrete insulin and inhibit glucagon secretion. When glucose levels in the blood rise (usually after consuming food), GLP-1R activates, creating a signaling cascade to signal cAMP. After the signaling cascade, the final result is the secretion of insulin to the rest of the body. Discovered in 1990s while trying to understand the mechanism of GLP-1 action. The structure was determined using cryogenic electron microscopy. | ||
Revision as of 14:39, 28 March 2024
Glucagon-Like Peptide 1 Receptor (GLP1-R)
Introduction
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References
- ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
