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Revision as of 17:54, 1 April 2024

Glucose-dependent Insulinotropic Polypeptide Receptor

spinqualitylabelsall models Glucose-dependent Insulinotropic Polypeptide, 7RA3 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Figure 1. The coolest image of this protein EVAH!!! Contents 1 Introduction 1.1 History 2 General Structure 2.1 Subunit Architecture 2.2 Glucose-dependent Insulinotropic Polypeptide 2.3 Active Site 3 Associated Diseases 4 Medical Relevance 4.1 Tirzepatide Introduction History In 1902, Bayliss and Starling discover a pancreatic secretin involved in regulation of water homeostasis, giving rise to interest in pancreatic hormones. Shortly after, in 1906, Moore et al. hypothesize involvement of hormone gut extracts in maintenance of the endocrine pancreas. General Structure Subunit Architecture Glucose-dependent Insulinotropic Polypeptide Active Site Figure 2. Crucial interaction between Tyr1 of GIP and corresponding GIPR residues. Associated Diseases Medical Relevance Tirzepatide

References

^[1]

1. ↑ Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW. Structural determinants of dual incretin receptor agonism by tirzepatide. Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2116506119. PMID:35333651 doi:10.1073/pnas.2116506119

Student Contributors

• Camille Gaudet