User:Camille Gaudet/Sandbox 1
From Proteopedia
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== Introduction == | == Introduction == | ||
=== History === | === History === | ||
| - | In 1902, [https://en.wikipedia.org/wiki/William_Bayliss Bayliss] and [https://en.wikipedia.org/wiki/Ernest_Starling Starling] discover a pancreatic [https://en.wikipedia.org/wiki/Secretin secretin] involved in regulation of water homeostasis, giving rise to interest in pancreatic hormones. Shortly after, in 1906, Moore et al. hypothesize involvement of [https://en.wikipedia.org/wiki/Gastrointestinal_hormone gastrointestinal hormone extracts] in maintenance of the endocrine pancreas. | + | In 1902, [https://en.wikipedia.org/wiki/William_Bayliss Bayliss] and [https://en.wikipedia.org/wiki/Ernest_Starling Starling] discover a pancreatic [https://en.wikipedia.org/wiki/Secretin secretin] involved in regulation of water homeostasis, giving rise to interest in pancreatic hormones. Shortly after, in 1906, Moore et al. hypothesize involvement of [https://en.wikipedia.org/wiki/Gastrointestinal_hormone gastrointestinal hormone extracts] in maintenance of the endocrine pancreas. Jean La Barre purifies glucose-lowering gut extracts in 1929 and characterizes them as [https://en.wikipedia.org/wiki/Incretin incretins], which stands for intestine secretion insulin. Finally, in 1984, gastric inhibitory peptide (or, GIP) is isolated from porcupine intestine. Although GIP was initially found to have gastric inhibitory effects, it was also shown that the polypeptide initiated insulin secretion. Interestingly, the effect of GIP on insulin levels was still seen in its absence, signaling the presence of an additional incretin, which has now been classified as glucagon-like peptide-1 (GLP-1). |
== General Structure == | == General Structure == | ||
Revision as of 13:08, 2 April 2024
Glucose-dependent Insulinotropic Polypeptide Receptor
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References
- ↑ Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW. Structural determinants of dual incretin receptor agonism by tirzepatide. Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2116506119. PMID:35333651 doi:10.1073/pnas.2116506119
Student Contributors
- Camille Gaudet
