1reu

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[[Image:1reu.jpg|left|200px]]
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{{STRUCTURE_1reu| PDB=1reu | SCENE= }}
{{STRUCTURE_1reu| PDB=1reu | SCENE= }}
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'''Structure of the bone morphogenetic protein 2 mutant L51P'''
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===Structure of the bone morphogenetic protein 2 mutant L51P===
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==Overview==
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Bone morphogenetic protein-2 (BMP-2) and other members of the TGF-beta superfamily regulate the development, maintenance and regeneration of tissues and organs. Binding epitopes for these extracellular signaling proteins have been defined, but hot spots specifying binding affinity and specificity have so far not been identified. In this study, mutational and structural analyses show that epitopes of BMP-2 and the BRIA receptor form a new type of protein-protein interface. The main chain atoms of Leu 51 and Asp53 of BMP-2 represent a hot spot of binding to BRIA. The BMP-2 variant L51P was deficient in type I receptor binding only, whereas its overall structure and its binding to type II receptors and modulator proteins, such as noggin, were unchanged. Thus, the L51P substitution converts BMP-2 into a receptor-inactive inhibitor of noggin. These results are relevant for other proteins of the TGF-beta superfamily and provide useful clues for structure-based drug design.
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(as it appears on PubMed at http://www.pubmed.gov), where 15064755 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15064755}}
==About this Structure==
==About this Structure==
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[[Category: Zhang, J L.]]
[[Category: Zhang, J L.]]
[[Category: Tgf-beta fold]]
[[Category: Tgf-beta fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:24:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:01:05 2008''

Revision as of 12:01, 27 July 2008

Image:1reu.png

Template:STRUCTURE 1reu

Structure of the bone morphogenetic protein 2 mutant L51P

Template:ABSTRACT PUBMED 15064755

About this Structure

1REU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular recognition of BMP-2 and BMP receptor IA., Keller S, Nickel J, Zhang JL, Sebald W, Mueller TD, Nat Struct Mol Biol. 2004 May;11(5):481-8. Epub 2004 Apr 4. PMID:15064755

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