9avg
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Structure of human calcium-sensing receptor in complex with chimeric Gs (miniGis) protein in nanodiscs== |
| - | + | <StructureSection load='9avg' size='340' side='right'caption='[[9avg]], [[Resolution|resolution]] 3.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9avg]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9AVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9AVG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9IG:3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine'>9IG</scene>, <scene name='pdbligand=A1AF7:(19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl+(9Z)-octadec-9-enoate'>A1AF7</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TCR:CYCLOMETHYLTRYPTOPHAN'>TCR</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9avg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9avg OCA], [https://pdbe.org/9avg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9avg RCSB], [https://www.ebi.ac.uk/pdbsum/9avg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9avg ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/CASR_HUMAN CASR_HUMAN] Autosomal dominant hypocalcemia;Familial isolated hypoparathyroidism due to impaired PTH secretion;Neonatal severe primary hyperparathyroidism;Familial hypocalciuric hypercalcemia type 1;Bartter syndrome with hypocalcemia. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Homozygous defects in CASR can be a cause of primary hyperparathyroidism in adulthood. Patients suffer from osteoporosis and renal calculi, have marked hypercalcemia and increased serum PTH concentrations. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CASR_HUMAN CASR_HUMAN] Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Asher WB]] | ||
| + | [[Category: Clarke OB]] | ||
| + | [[Category: Conigrave AD]] | ||
| + | [[Category: Eng E]] | ||
| + | [[Category: Fan QR]] | ||
| + | [[Category: Frangaj A]] | ||
| + | [[Category: Grasucci R]] | ||
| + | [[Category: Hendrickson WA]] | ||
| + | [[Category: Hu G]] | ||
| + | [[Category: Javitch JA]] | ||
| + | [[Category: Lin X]] | ||
| + | [[Category: Lu G]] | ||
| + | [[Category: Lu Z]] | ||
| + | [[Category: Manning JJ]] | ||
| + | [[Category: Mendez J]] | ||
| + | [[Category: Park J]] | ||
| + | [[Category: Wang L]] | ||
| + | [[Category: Ye J]] | ||
| + | [[Category: Zhang Z]] | ||
| + | [[Category: Zuo H]] | ||
Revision as of 05:32, 17 April 2024
Structure of human calcium-sensing receptor in complex with chimeric Gs (miniGis) protein in nanodiscs
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Categories: Homo sapiens | Large Structures | Asher WB | Clarke OB | Conigrave AD | Eng E | Fan QR | Frangaj A | Grasucci R | Hendrickson WA | Hu G | Javitch JA | Lin X | Lu G | Lu Z | Manning JJ | Mendez J | Park J | Wang L | Ye J | Zhang Z | Zuo H
