1txu
From Proteopedia
(New page: 200px<br /> <applet load="1txu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1txu, resolution 2.35Å" /> '''Crystal Structure o...) |
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caption="1txu, resolution 2.35Å" /> | caption="1txu, resolution 2.35Å" /> | ||
'''Crystal Structure of the Vps9 Domain of Rabex-5'''<br /> | '''Crystal Structure of the Vps9 Domain of Rabex-5'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1TXU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1TXU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXU OCA]. |
==Reference== | ==Reference== | ||
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[[Category: vps9 domain]] | [[Category: vps9 domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:58:47 2008'' |
Revision as of 14:58, 15 February 2008
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Crystal Structure of the Vps9 Domain of Rabex-5
Overview
The Rab5 GTPase, an essential regulator of endocytosis and endosome, biogenesis, is activated by guanine-nucleotide exchange factors (GEFs), that contain a Vps9 domain. Here, we show that the catalytic core of the, Rab GEF Rabex-5 has a tandem architecture consisting of a Vps9 domain, stabilized by an indispensable helical bundle. A family-wide analysis of, Rab specificity demonstrates high selectivity for Rab5 subfamily GTPases., Conserved exchange determinants map to a common surface of the Vps9, domain, which recognizes invariant aromatic residues in the switch regions, of Rab GTPases and selects for the Rab5 subfamily by requiring a small, nonacidic residue preceding a critical phenylalanine in the switch I, region. These and other observations reveal unexpected similarity with the, Arf exchange site in the Sec7 domain.
About this Structure
1TXU is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5., Delprato A, Merithew E, Lambright DG, Cell. 2004 Sep 3;118(5):607-17. PMID:15339665
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