4pqz
From Proteopedia
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/SWT1_YEAST SWT1_YEAST] Involved in transcription. Probably functions as a transcriptional activator.<ref>PMID:16464826</ref> <ref>PMID:17030511</ref> | [https://www.uniprot.org/uniprot/SWT1_YEAST SWT1_YEAST] Involved in transcription. Probably functions as a transcriptional activator.<ref>PMID:16464826</ref> <ref>PMID:17030511</ref> | ||
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| + | == Publication Abstract from PubMed == | ||
| + | Swt1 is an RNA endonuclease that plays an important role in quality control of nuclear messenger ribonucleoprotein particles (mRNPs) in eukaryotes; however, its structural details remain to be elucidated. Here, we report the crystal structure of the C-terminal (CT) domain of Swt1 from Saccharomyces cerevisiae, which shares common characteristics of higher eukaryotes and prokaryotes nucleotide binding (HEPN) domain superfamily. To study in detail the full-length protein structure, we analyzed the low-resolution architecture of Swt1 in solution using small angle X-ray scattering (SAXS) method. Both the CT domain and middle domain exhibited a good fit upon superimposing onto the molecular envelope of Swt1. Our study provides the necessary structural information for detailed analysis of the functional role of Swt1, and its importance in the process of nuclear mRNP surveillance. | ||
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| + | High-resolution crystal structure reveals a HEPN domain at the C-terminal region of S. cerevisiae RNA endonuclease Swt1.,Peng S, Zhou K, Wang W, Gao Z, Dong Y, Liu Q Biochem Biophys Res Commun. 2014 Oct 16;453(4):826-832. doi:, 10.1016/j.bbrc.2014.10.040. PMID:25450355<ref>PMID:25450355</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4pqz" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
Crystal structure of swt1 C-terminal domain from yeast
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