1rhw

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{{STRUCTURE_1rhw| PDB=1rhw | SCENE= }}
{{STRUCTURE_1rhw| PDB=1rhw | SCENE= }}
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'''The solution structure of the pH-induced monomer of dynein light chain LC8 from Drosophila'''
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===The solution structure of the pH-induced monomer of dynein light chain LC8 from Drosophila===
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==Overview==
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The structure of Drosophila LC8 pH-induced monomer has been determined by NMR spectroscopy using the program AutoStructure. The structure at pH 3 and 30 degrees C is similar to the individual subunits of mammalian LC8 dimer with the exception that a beta strand, which crosses between monomers to form an intersubunit beta-sheet in the dimer, is a flexible loop with turnlike conformations in the monomer. Increased flexibility in the interface region relative to the rest of the protein is confirmed by dynamic measurements based on (15)N relaxation. Comparison of the monomer and dimer structures indicates that LC8 is not a domain swapped dimer.
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(as it appears on PubMed at http://www.pubmed.gov), where 14767079 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14767079}}
==About this Structure==
==About this Structure==
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1RHW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RHW OCA].
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1RHW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RHW OCA].
==Reference==
==Reference==
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[[Category: Dimer interface]]
[[Category: Dimer interface]]
[[Category: Domain swapped]]
[[Category: Domain swapped]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:30:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:55:35 2008''

Revision as of 18:55, 27 July 2008

Image:1rhw.png

Template:STRUCTURE 1rhw

The solution structure of the pH-induced monomer of dynein light chain LC8 from Drosophila

Template:ABSTRACT PUBMED 14767079

About this Structure

1RHW is a Single protein structure of sequence from Drosophila melanogaster. Full experimental information is available from OCA.

Reference

The solution structure of the pH-induced monomer of dynein light-chain LC8 from Drosophila., Makokha M, Huang YJ, Montelione G, Edison AS, Barbar E, Protein Sci. 2004 Mar;13(3):727-34. Epub 2004 Feb 6. PMID:14767079

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