1rid

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{{STRUCTURE_1rid| PDB=1rid | SCENE= }}
{{STRUCTURE_1rid| PDB=1rid | SCENE= }}
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'''Vaccinia Complement Protein in Complex with Heparin'''
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===Vaccinia Complement Protein in Complex with Heparin===
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==Overview==
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Vaccinia virus complement control protein (VCP), a homolog of the regulators of the complement activation family of proteins, inhibits complement activation through mechanisms similar to human fluid-phase complement regulators factor H and C4b-binding protein. VCP has a heparin-binding activity that assists vaccinia in host interactions. Interaction with cell-surface polyanions like heparin is centrally important in the functioning of fluid-phase complement regulators and is the basis of host-target discrimination by the alternative pathway. We report the structure of VCP in complex with a heparin decasaccharide, which reveals changes in VCP that might be pertinent to complement regulation. Properties that VCP shares with fluid-phase complement regulators suggest that such conformational changes may be of relevance in the functioning of other complement regulators. Additionally, comparison of VCP-heparin interactions with potentially similar interactions in factor H might enable understanding of the structural basis of familial hemolytic uremic syndrome, attributed to mutational disruption of heparin and C3b binding by factor H.
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(as it appears on PubMed at http://www.pubmed.gov), where 15178763 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15178763}}
==About this Structure==
==About this Structure==
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[[Category: Regulation]]
[[Category: Regulation]]
[[Category: Scr]]
[[Category: Scr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:31:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:18:58 2008''

Revision as of 04:19, 28 July 2008

Image:1rid.png

Template:STRUCTURE 1rid

Vaccinia Complement Protein in Complex with Heparin

Template:ABSTRACT PUBMED 15178763

About this Structure

1RID is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.

Reference

Structure of vaccinia complement protein in complex with heparin and potential implications for complement regulation., Ganesh VK, Smith SA, Kotwal GJ, Murthy KH, Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8924-9. Epub 2004 Jun 3. PMID:15178763

Page seeded by OCA on Mon Jul 28 07:18:58 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA, Eric Martz

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