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VprBP

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Current revision (08:47, 3 April 2024) (edit) (undo)
 
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The interactions between VprBP and Vpr are located in a cleft formed by <scene name='77/776391/Cv/10'>VprBD canonical WD40 seven-blade β-propeller</scene> ({{Template:ColorKey_Helix}}, {{Template:ColorKey_Strand}}, {{Template:ColorKey_Loop}}, {{Template:ColorKey_Turn}}) which is <scene name='77/776391/Cv/11'>lined by acidic residues on one end and hydrophobic residues at the center</scene> ({{Template:ColorKey_Charge_Anionic}} / {{Template:ColorKey_Charge_Cationic}}; {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}). The interactions are formed by <scene name='77/776391/Cv/12'>hydrogen bonds</scene>, <scene name='77/776391/Cv/13'>Vpr Phe residue buried in VprBP hydrophobic pocket</scene> and <scene name='77/776391/Cv/14'>VprBP Trp binding to residues in Vpr pocket</scene><ref>PMID:27571178</ref>.
The interactions between VprBP and Vpr are located in a cleft formed by <scene name='77/776391/Cv/10'>VprBD canonical WD40 seven-blade β-propeller</scene> ({{Template:ColorKey_Helix}}, {{Template:ColorKey_Strand}}, {{Template:ColorKey_Loop}}, {{Template:ColorKey_Turn}}) which is <scene name='77/776391/Cv/11'>lined by acidic residues on one end and hydrophobic residues at the center</scene> ({{Template:ColorKey_Charge_Anionic}} / {{Template:ColorKey_Charge_Cationic}}; {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}). The interactions are formed by <scene name='77/776391/Cv/12'>hydrogen bonds</scene>, <scene name='77/776391/Cv/13'>Vpr Phe residue buried in VprBP hydrophobic pocket</scene> and <scene name='77/776391/Cv/14'>VprBP Trp binding to residues in Vpr pocket</scene><ref>PMID:27571178</ref>.
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</StructureSection>
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== 3D Structures of VprBP ==
== 3D Structures of VprBP ==
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[[VprBP 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[4pxw]] – hVprBP residues 1039-1401 (mutant) - human <br />
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[[3wa0]] – hVprBP residues 1417-1506 + merlin <br />
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[[4p7i]] – hVprBP residues 998-1058 + merlin <br />
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[[4z8l]], [[5aja]], [[4cc9]] – hVprBP residues 1057-1396 + VPX + SAMHD1 <br />
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[[5jk7]] – hVprBP residues 1045-1396 + Vpr + DNA damage-binding protein + uracil-DNA glycosylase <br />
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human VprBP residues 1045-1396 (pink) complex with Vpr (cyan), DNA damage-binding protein (green) and uracil-DNA glycosylase (yellow) (PDB code 5jk7)

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Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky

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