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User:Isabel Kluszynski/Sandbox 1

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<ref name=”Zhao”>PMID:35217653</ref>
<ref name=”Zhao”>PMID:35217653</ref>
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==Structure and Function==
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==Structure and Function==
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Makenna made these scenes.
<scene name='10/1037490/Whole_protein/2'>GLP1 Bound to GLP-1R</scene>
<scene name='10/1037490/Whole_protein/2'>GLP1 Bound to GLP-1R</scene>
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===Binding Interactions of GLP1===
===Binding Interactions of GLP1===
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Isabel made these scenes.
<scene name='10/1037487/Nterm_residues/5'>N term Binding Interactions</scene>
<scene name='10/1037487/Nterm_residues/5'>N term Binding Interactions</scene>
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===Binding Interactions of Tirzepatide===
===Binding Interactions of Tirzepatide===
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Makenna made these scenes.
<scene name='10/1037490/Tirzepatidebonding/2'>Binding Interactions</scene>
<scene name='10/1037490/Tirzepatidebonding/2'>Binding Interactions</scene>
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===Comparison of Binding Interactions===
===Comparison of Binding Interactions===
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<scene name='10/1037490/Overlay/1'>Overlay</scene>
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Makenna made first overlay scene and Isabel made the other two scenes here.
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<scene name='10/1037490/Overlay/2'>N term Residues</scene>
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<scene name='10/1037490/Overlay/1'>Overlay</scene>
<scene name='10/1037487/Overlay/2'>Pi Stacking</scene>
<scene name='10/1037487/Overlay/2'>Pi Stacking</scene>

Revision as of 22:14, 10 April 2024

GLP-1R Homo Sapiens

GLP-1R 6X18

Drag the structure with the mouse to rotate

References

  1. ↑ Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Šenel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D. Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists. Mol Cell. 2020 Nov 5;80(3):485-500.e7. PMID:33027691 doi:10.1016/j.molcel.2020.09.020
  2. ↑ Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW. Structural determinants of dual incretin receptor agonism by tirzepatide. Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2116506119. PMID:35333651 doi:10.1073/pnas.2116506119
  3. ↑ Seino Y, Fukushima M, Yabe D. GIP and GLP-1, the two incretin hormones: Similarities and differences. J Diabetes Investig. 2010 Apr 22;1(1-2):8-23. PMID:24843404 doi:10.1111/j.2040-1124.2010.00022.x
  4. ↑ Mayendraraj A, Rosenkilde MM, Gasbjerg LS. GLP-1 and GIP receptor signaling in beta cells interactions and co-stimulation. Peptides. 2022 May;151:170749. PMID:35065096 doi:10.1016/j.peptides.2022.170749
  5. ↑ Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW. Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nat Commun. 2022 Feb 25;13(1):1057. PMID:35217653 doi:10.1038/s41467-022-28683-0

Student Contributors

  • Isabel Kluszynski
  • Makenna Marcinek

Proteopedia Page Contributors and Editors (what is this?)

Isabel Kluszynski

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