User:Brynn Baker/Sandbox1

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Homo sapiens Amylin3 Receptor, AMYR3

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You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

1 Introduction
2 Amylin
- 2.1 Amidated C-Terminus
3 G-Coupled Protein Receptor Interactions
4 RAMPs
5 Amylin Receptor Functional Overview
- 5.1 Key Interactions
6 Disease
7 Relevance
8 Structural highlights

Introduction

Figure 1. The coolest image of this protein EVAH!!!

The human amylin receptor is a G-coupled protein receptor.

Amylin

Amylin is a neuroendocrine hormone that is synthesized with insulin in the beta cells of pancreatic islets. It can cross the blood-brain barrier and regulates glucose homeostasis via inhibiting gastric emptying, inhibiting the release of glucagon, and inducing meal-ending satiety. In doing so, it prevents spikes in blood glucose and overeating, making it a suitable target for Type 2 Diabetes. Type 2 Diabetes treatments and therapies. Seeing as Type 2 Diabetes is a major risk factor for Alzheimer's Disease, as Type 2 Diabetes cases continue to increase, there will likely be a spike in Alzheimer’s Disease as well. Therefore, it is vital that amylin, its receptor, and analogs such as pramlintide are understood to aid in rational drug design.

Amidated C-Terminus

G-Coupled Protein Receptor Interactions

RAMPs

Amylin Receptor Functional Overview

Key Interactions

The aids in amylin affinity and the formation of the AMYR3. The of the amylin is a very interesting mutation.

Disease

Pramlintide Analogue

Type 2 Diabetes

Alzheimer's Disease

The proline mutations can help prevent disease. ^[3]

Relevance

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

References

↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677

Student Contributors

Brynn Baker
Emily Berkman
Sepp Hall

Proteopedia Page Contributors and Editors (what is this?)

Brynn Baker

Retrieved from "http://52.214.119.220/wiki/index.php/User:Brynn_Baker/Sandbox1"

@@ Line 7: / Line 7: @@
 The human amylin receptor is a [https://en.wikipedia.org/wiki/G_protein-coupled_receptor G-coupled protein receptor].
 == Amylin ==
-Amylin is a neuroendocrine hormone that is synthesized with insulin in the [https://en.wikipedia.org/wiki/Beta_cell beta cells] of pancreatic islets. It can cross the [https://en.wikipedia.org/wiki/Blood%E2%80%93brain_barrier blood-brain barrier] and regulates glucose homeostasis via inhibiting gastric emptying, inhibiting the release of glucagon, and inducing meal-ending satiety. In doing so, it prevents spikes in blood glucose and overeating, making it a suitable target for Type II Diabetes treatments and therapies. Seeing as Type II Diabetes is a major risk factor for Alzheimer’s Disease, as Type II Diabetes cases continue to increase, there will likely be a spike in Alzheimer’s Disease as well. Therefore, it is vital that amylin, its receptor, and analogs such as pramlintide are understood to aid in rational drug design.
+Amylin is a neuroendocrine hormone that is synthesized with insulin in the [https://en.wikipedia.org/wiki/Beta_cell beta cells] of pancreatic islets. It can cross the [https://en.wikipedia.org/wiki/Blood%E2%80%93brain_barrier blood-brain barrier] and regulates glucose homeostasis via inhibiting gastric emptying, inhibiting the release of glucagon, and inducing meal-ending satiety. In doing so, it prevents spikes in blood glucose and overeating, making it a suitable target for [https://en.wikipedia.org/wiki/Type_2_diabetes Type 2 Diabetes]. Type 2 Diabetes treatments and therapies. Seeing as Type 2 Diabetes is a major risk factor for [https://en.wikipedia.org/wiki/Alzheimer%27s_disease Alzheimer's Disease], as Type 2 Diabetes cases continue to increase, there will likely be a spike in Alzheimer’s Disease as well. Therefore, it is vital that amylin, its receptor, and analogs such as pramlintide are understood to aid in rational drug design.
 === Amidated C-Terminus ===
 == G-Coupled Protein Receptor Interactions ==
@@ Line 20: / Line 20: @@
 == Disease ==
 === Pramlintide Analogue ===
-=== Type II Diabetes ===
+=== Type 2 Diabetes ===
 === Alzheimer's Disease ===
 The proline mutations can help prevent disease. <ref name="Ransey">PMID:28504306</ref>