1rjc

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{{STRUCTURE_1rjc| PDB=1rjc | SCENE= }}
{{STRUCTURE_1rjc| PDB=1rjc | SCENE= }}
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'''Crystal structure of the camelid single domain antibody cAb-Lys2 in complex with hen egg white lysozyme'''
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===Crystal structure of the camelid single domain antibody cAb-Lys2 in complex with hen egg white lysozyme===
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==Overview==
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A central paradigm in immunology states that successful generation of high affinity antibodies necessitates an immense primary repertoire of antigen-combining sites. Much of the diversity of this repertoire is provided by varying one antigen binding loop, created by inserting randomly a D (diversity) gene out of a small pool between the V and J genes. It is therefore assumed that any particular D-encoded region surrounded by different V and J regions adopts a different conformation. We have solved the structure of two lysozyme-specific variable domains of heavy-chain antibodies isolated from two strictly unrelated dromedaries. These antibodies recombined identical D gene sequences to different V and J precursors with significant variance in their V(D)J junctions. Despite these large differences, the D-encoded loop segments adopt remarkably identical architectures, thus directing the antibodies toward identical epitopes. Furthermore, a striking convergent maturation process occurred in the V region, adapting both binders for their sub-nanomolar affinity association with lysozyme. Hence, on a structural level, humoral immunity may rely more on well developed maturation and selection systems than on the acquisition of large primary repertoires.
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The line below this paragraph, {{ABSTRACT_PUBMED_15659390}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15659390 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15659390}}
==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
[[Category: Protein-protein hetero complex]]
[[Category: Protein-protein hetero complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:33:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:26:44 2008''

Revision as of 04:26, 28 July 2008

Image:1rjc.png

Template:STRUCTURE 1rjc

Crystal structure of the camelid single domain antibody cAb-Lys2 in complex with hen egg white lysozyme

Template:ABSTRACT PUBMED 15659390

About this Structure

1RJC is a Single protein structure of sequence from Camelus dromedarius and Gallus gallus. Full crystallographic information is available from OCA.

Reference

Strong in vivo maturation compensates for structurally restricted H3 loops in antibody repertoires., De Genst E, Silence K, Ghahroudi MA, Decanniere K, Loris R, Kinne J, Wyns L, Muyldermans S, J Biol Chem. 2005 Apr 8;280(14):14114-21. Epub 2005 Jan 19. PMID:15659390

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